Application of an insecticide to control mosquito populations in malaria infested areas quickly resulted in a dominant mutation, R, resulting in insecticide resistance. However, the mutation also reduces the fertility of RR homozygotes. The fitness of different genotypes in areas where the insecticide is in use, are as follows:
rr (susceptible) 0.35
Rr (resistant) 1.0
RR (resistant) 0.85
What is the equilibrium frequency of the R allele in the population? Using the fitness values in the previous problem, and a starting frequency of 1% for the R allele, what is the expected frequency of the R allele after one generation in an environment where the insecticide is applied?
