Depletion of NADPH and glutathione in cells is considered harmful. Explain why, and give an example of a chemical that may deplete NADPH and glutathione through interaction with the FMO enzyme. The FMO3 enzyme has an important physiological function in people. State the normal substrate of FMO3 in people and describe a genetic polymorphism that can reduce the activity of this enzyme. Describe the consequence to people with the reduced FMO3 activity.
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