AKT Phopshorylation COLLAPSE AKT phosphorylation can indicate prognosis for cancer diagnosis in most cases, phosphorylation of itself or other family members will mean more agressive disease with a poorer prognosis. However, there are some instances (eg. tumor supressors) where phosphorylation might result in more active suppression of disease. it really depends on what you are pohosphorylating. Give this article a read and aIDress the points listed in the assignment.