Outline knudson multistage theory of cancer

1:What types of evidence indicate that cancer arises from genetic changes?
2: Discuss how is cancer different from most other types of genetic diseases?
3:Outline Knudson’s multistage theory of cancer and describe how it helps to explain unilateral and bilateral cases of retinoblastoma.
4:What is haploinsufficiency? How might it affect cancer risk?
5:What role do telomeres and telomerase play in cancer progression?
6:Explain how chromosome deletions, inversions, and translations may cause cancer.
7:What is genomic instability? Give some ways in which genomic instability may
8:How is an epigenetic change different from a mutation?
9:How is DNA methylation related to cancer?
10:What is a Mendelian population? How is the gene pool of a Mendelian population usually described?
11:What are the predictions given by the Hardy Weinberg law?
12:What is random mating?
13:Define inbreeding and briefly describe its effects on a population.
14:Define inbreeding and briefly describe its effects on a population.
15:What determines the allelic frequencies at mutational equilibrium?

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