List the stages of leukocyte maturation in order

Hematology/Phlebotomy

Module Reading & Objectives

Reading

Keohane Textbook 5th Edition

· Chapter 8: Erythrocyte Production and Destruction

o Review chapter sections as needed to clarify lecture materials

· Chapter 9: Erythrocyte Metabolism and Membrane Structure

o Review chapter sections as needed to clarify lecture materials

· Chapter 10: Hemoglobin Metabolism

o Review chapter sections as needed to clarify lecture materials

· Chapter 12: Leukocyte Development, Kinetics and Functions

o Review chapter sections as needed to clarify lecture materials

· Chapter 13: Platelet Production, Structure and Function

o Review chapter sections as needed to clarify lecture materials

Objectives

1. Define the Normoblastic Maturation nomenclature and which one is commonly used in the US. (Ch 8)

2. List the stages of Erythrocyte maturation in order. (Ch 8)

3. Compare and contrast the features in the stages of maturation seen in the Erythrocyte. (Ch 8)

4. Explain the role of EPO in erythropoiesis. (Ch 8)

5. Summarize extravascular hemolysis and Intravascular Hemolysis and their differences. (Ch 8)

6. Describe the importance of the RBC membrane and its deformability. (Ch 9)

7. Summarize structure of hemoglobin. (Ch 10)

8. List the different hemoglobins seen in the following (Ch 10):

o Fetus
o Newborn
o Adult

9. Describe the function of hemoglobin (Ch 10)

10. List the reference ranges for hemoglobin in (Ch 10):

o Men, Women, Newborns

11.Discuss the different dyshemoglobins, including symptoms, causes and treatments. (Ch 10)

12.Identify the differences between Granulocyte and Mononuclear Classifications. (Ch12)

13.List the stages of Leukocyte maturation in order. (Ch 12)

14.Compare and contrast the features in the stages of maturation seen in the Neutrophils, Eosinophils, Basophils, Monocytes, and Lymphocytes (Ch 12).

15.Explain the functions of the Neutrophil, Eosinophils, Basophil, Monocyte and Lymphocyte. (Ch 12)

16.List the reference ranges that can be seen for leukocytes in circulation. (Ch 12)

17.List the stages of Leukocyte maturation in order. (Ch 13)

18.Compare and contrast the features in the stages of maturation seen in platelet production (Ch 13).

19.Discuss the differences and causes of platelet clumping and platelet satellitism. (Ch 13)

20.Define the function platelets and explain their role in the 4 phases of primary hemostasis. (Ch 13)

21.List the reference range for platelets. (Ch 13)

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