A man has a heritable disease, which his father suffers from, along with his son. His father’s symptoms are comparatively light, where his sons are profound and seen at a much earlier age. What is a good explanation for the mechanism that is causing this inheritance pattern?
- trinucleotide repeats are aIDed every generation to a region of DNA
- each successive generation gains a new mutation in a different loci on the chromosomes
- the mothers do not have the diseases badly because they are females, and are protected from X linked recessive phenotypes because of an XX karyotype
- DNA that has gained a mutation is much easier to mutate each successive generation