Changing ion transport from the filtrate

Question: A new drug targets renal function by changing ion transport from the filtrate to the interstitial fluid. This particular medicine blocks active transport of sodium in the nephrons. Discuss how would this affect the osmoregulation in the kidneys? Consider the osmolarity at the Renal Corpuscle, Proximal Convoluted Tubule, Descending loop of henle, ascending loop of henle, distal convoluted tubule, collecting duct, renal pelvis.